Kinda easy actually,
I have my computer hooked up to my large screen television and to my monitor at my desk. (Two Different rooms) And I have the screens cloned. When I'm sitting on the couch, it is easier to see the text when it is set to Larger - 150% in windows 7. But when I'm sitting at my desk working, I guess that screws everything up. So, I had to take it back to medium or smaller. Forget now, I'm at the office... But after, I did that... My text wouldn't get larger when the properties box was docked...
I wish there was a way, to keep it two different set ups.. But this works for now..